With our innovative technology and experience, we support the most challenging structure based discovery and quality control efforts. Karl Bertram, Founder of ATEM Structural DiscoveryĪTEM Structural Discovery is dedicated to offering state-of-the-art cryo-EM centered solutions, at scale, to its clients in the pharmaceutical and biotechnological industries. ATEM offers deep and leading technical expertise, which combined with Charles River’s market reach will help us to serve a rapidly growing market need." – Dr. We are excited to partner with Charles River to build and offer these services at scale to their clients. "The tremendous advances in cryo-EM technology are now enabling a large number of new and innovative possibilities in both structural biology and manufacturing or R&D related quality control applications. ATEM’s cryo-EM expertise is a perfect complement to our established x-ray crystallography platform." – Grant Wishart, Director CADD & Structural Biology, Discovery, Charles River
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"Cryo-EM will expand the portfolio of drug targets that we can generate a 3D understanding of, enhance our knowledge of how to modulate these targets and enable computational drug design for more of our client projects. By expanding our technology services through strategic partnerships, we’re able to nimbly assess and meet our client’s needs, while providing innovative solutions to accelerate their drug discovery and development." – Birgit Girshick, Corporate Executive Vice President, Discovery and Safety Assessment and Biologics Solutions, Charles River "We’re very excited to offer ATEM’s cryo-EM platform to our clients. Additionally, cryo-EM allows the use of minimal amounts of sample, fast turn-around times, and improved statistical accuracy.įor recombinant protein drugs, ATEM’s models will provide fast track virus particle analysis as part of the adventitious agent testing on cell banks and bulk harvest samples, along with support for the development and optimization of downstream purification efforts through rapid TEM-based impurity screening and visualization. By utilizing technologies including analytical ultracentrifugation (AUC), capillary isoelectric focusing (cIEF), transmission electron microscopy (TEM), and cryo-EM, clients can expect to receive qualitative and quantitative data to ensure improved dosing accuracy. full/empty capsid ratio analysis), as well as novel mRNA and plasmid-based drugs. This leads to the identification of novel distinct binding sites and significantly improves the discovery of drug candidates.ĪAV Capsid Ratio Analysis and mRNA Formulation Development in Support of Gene TherapiesĬryo-EM has become a powerful orthogonal tool to support both quality control and research and development (R&D) efforts in adeno-associated virus (AAV) vector-based gene therapies (i.e. Subsequently, reconstructed coulomb potential maps then allow the precise modeling of 3D atomic coordinates that elucidate the target structure. ATEM’s technology directly images vitrified biological macromolecules in single-particle experiments at high resolution.
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Cryo-EM is a technique that determines the 3D structures of proteins and is utilized to identify how proteins function, how they malfunction in disease and the most effective way to target them with therapies.ĪTEM’s leading platform integrates highly optimized biochemistry, hardware, and software to provide in-depth structural insights about challenging targets at a commercial scale. (NYSE: CRL) and ATEM Structural Discovery (ATEM) today announced the formation of a strategic partnership to provide clients access to ATEM’s cryo-electron microscopy (cryo-EM) service solutions. WILMINGTON, Mass., October 18, 2021-( BUSINESS WIRE)-Charles River Laboratories International, Inc. Partnership will provide access to ATEM’s leading cryo-EM platform
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